CS 704B-Bio Informatics |
Module I:Introduction to Genomic data and Data Organization: |
Sequence Data Banks - Introduction to sequence date banks -
protein sequence data bank. NBFR-PIR, SWISSPROT, Signal peptide data bank, Nucleic acid sequence data bank -
GenBank, EMBL nucleotide sequence data bank, AIDS virus sequence data bank. RRNA data bank, structural data
banks - protein Data Bank (PDB), The Cambridge Structural Database (CSD) : Genome data bank - Metabolic pathway
data : Microbial and Cellular Data Banks.
|
Module II:Introduction to MSDN (Microbial Strain Data Network): |
Numerical Coding Systems of Microbes, Hibridoma Data
Bank Structure, Virus Information System Cell line information system; other important Data banks in the area of
Biotechnology/life sciences/biodiversity.
Sequence analysis: Analysis Tools for Sequence Data Banks; Pair wise alignment -NEEDLEMAN and Wunsch
algorithm, Smith Waterman, BLAST, FASTA algorithms to analyze sequence data: Sequence patterns motifs and
profiles.
|
Module III: |
Secondary Structure predictions; prediction algorithms; Chao-Fasman algorithm, Hidden-Markov model, Neural
Networking.
Tertiary Structure predictions; prediction algorithms; Chao-Fasman algorithm, Hidden-Markov model, Neural
Networking.
|
Module IV: |
Applications in Biotechnology: Protein classifications, Fold libraries, Protein structure prediction: Fold recognition
(threading), Protein structure predictions : Comparative modeling (Homology), Advanced topics: Protein folding,
Protein-ligand interactions, Molecular Modeling & Dynamics, Drug Designing.
|
Text Books: |
1. Lesk, Introduction to Bio Informatics, OUP
2. Introduction to Bioinformatics, Atwood, Pearson Education
3. Developing Bioinformatics Computer Skills, Cynthia Gibas and Per Jambeck, 2001 SPD
4. Statistical Methods in Bioinformatics, Springer India
5. Beginning Perl for Bio-informatics, Tisdall, SPD
6. Biocomputing: Informatics and Genome Project, Smith, D.W., 1994, Academic Press, NY
7. Bioinformatics: A practical Guide to the Analysis of Genes and Proteins, Baxevanis, A.D., Quellette, B.F.F.,
John Wiely & Sons.
8. Murty CSV, Bioinfornmatics, Himalaya
|
|