Introduction – Importance of Bioinformatics – Biological Sequence Structure – Deficit –
Genome Projects – Status – Sequence analysis – Homology and analogy.
EMBNET – NCBI – virtual Tourism.
Primary Sequence Databases Biological data base – Primary Sequence Database – Composite
Protein Sequence Database – Secondary Database - Composite Protein – Pattern database
structure and classification of database.
Genome Information Resources - DNA Sequence data base – Specialised genomic Resources.
DNA Sequence analysis : Why analyse DNA? – Gene structure – Features of DNA sequence
analysis – Issues in the interpretation and EST search – Approach of Gene hunting – Cell
CDNA libraries and ESTs – Approaches to EST analysis – Effect of EST data on DNA data
base examples of EST analysis.
Data Base Searchers and Pair Wise Alignment Data base searching – Alphabets and
Complexity – Comparing Two Sequences – Sub-Sequence – Identity and Similarity – Dot plots
– Simple alignment – Gaps – Scoring Matrices – Dynamic programming – BLAST and its
relative – FSTA and related algorithms – Alignment scores and statistical significance of data
base sequences.
Global and local Alignments : Algorithms – Similarities – Semi global alignment
Multiple Sequence Alignment : Goal – Definition – Consensus – Complex – methods –
Database of multiple Alignment – searching database with multiple alignment.
Methods of Photo Genetics.: Distance Based Methods – Based Methods – Comparison.
RNA Structure: Amino Acids – Polypeptide Composition Algorithm – Modeling protein
folding prediction – RNA Sequence Structure.
Proteomics: Classification – Techniques – Inheritors – Drying Design – Structures – X-Ray
Crystal – NMR – Empirical methods and prediction techniques.