7 IT 6.3-BIO-INFORMATICS |
Units: I |
INTRODUCTION: Bioinformatics objectives and overviews, Interdisciplinary nature of
Bioinformatics, Data integration, Data analysis, Major Bioinformatics databases and tools.
Metadata: Summary & reference systems, finding new type of data online.
MOLECULAR BIOLOGY AND BIOINFORMATICS: Systems approach in biology, Central
dogma of molecular biology, problems in molecular approach and the bioinformatics
approach, Overview of the bioinformatics applications.
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Units: II |
THE INFORMATION MOLECULES AND INFORMATION FLOW: Basic chemistry of
nucleic acids, Structure of DNA, Structure of RNA, DNA Replication, -Transcription, -
Translation, Genes- the functional elements in DNA, Analyzing DNA,DNA sequencing.
Proteins: Amino acids, Protein structure, Secondary, Tertiary and Quaternary structure,
Protein folding and function, Nucleic acid-Protein interaction. |
Units: III |
PERL: Perl Basics, Perl applications for bioinformatics- Bioperl, Linux Operating System,
Understanding and Using Biological Databases, Java clients, CORBA, Introduction to
biostatics.
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Units: IV |
NUCLEOTIDE SEQUENCE DATA: Genome, Genomic sequencing, expressed sequence
tags, gene expression, transcription factor binding sites and single nucleotide polymorphism.
Computational representations of molecular biological data storage techniques: databases
(flat, relational and object oriented), and controlled vocabularies, general data retrieval
techniques: indices, Boolean search, fuzzy search and neighboring, application to biological
data warehouses.
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Units: V |
BIOLOGICAL DATA TYPES AND THEIR SPECIAL REQUIREMENTS: sequences,
macromolecular structures, chemical compounds, generic variability and its connection to
clinical data. Representation of patterns and relationships: alignments, regular expressions,
hierarchies and graphical models.
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